Informatics Institute faculty member Sefer Baday coauthored paper titled 'Synthesis, Computational Studies, and Anti-Tuberculosis Activity of Benzoxazines That Act as RAGE Inhibitors' has been published in 'Applied Microbiology' on 8th February 2023. 

DOI: https://doi.org/10.3390/applmicrobiol3010017

Abstract:
Novel benzoxazines were synthesized by microwave irradiation and tested for their potential binding affinity towards receptors of advanced glycation end products (RAGE). We found that the compound (2-(2-bromophenyl)-6-methyl-2,4-dihydro-1H-benzo[d][1,3]oxazine) (3i) is a lead inhibitor of RAGE. Further, our in silico prediction that benzoxazines dock towards the AGE binding region of RAGE suggests that these ligands could bind effectively at the hydrophobic pocket of the receptor and additionally form key interactions with Arg48 and Arg104, revealing its diversity in developing anti-RAGE drugs to treat AGE–RAGE-dominant disease conditions. Functionally, we herein report the anti-tuberculosis activity of small molecules which could be bioactive in the culture of mycobacterium tuberculosis.

İTÜ Informatics Institute

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ITU Informatics Institute provides graduate-level education and research in applied informatics, computer sciences, computational science and engineering, communication systems under the following programs.

Faculty members and students conduct research supported by national and international organızatıons in the fields of electromagnetic fields, communication systems/regulations, computational materials design, computational chemistry/biology, cryptography, signal/data processing/visualization, big data management, climate and ocean sciences, 

  • The paper titled “Non-Invasive Complete Hemodynamic Model to Investigate the Effect of Multi-Stenosis in Patient-Specific Coronary Arteries”, jointly prepared by research assistants Hacer Duzman and E. Cenk Ersan, andProf. Dr. M. Serdar Çelebi from the Computational Science and Engineering Program, has been awarded the Best Paper Award at the ESM’25. (22-24 Oct. 2025 Belgium)
  • Hacer Duzman and Muhammed Enis Şen, PhD students of Computational Science and Engineering Program, received awards in the "5 Minute Thesis Competition" organized at the "Başarım 2024 8th National High Performance Computing Conference".

There is also a High Performance Computing Laboratory established with the support of the State Planning Organization within the Institute.