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Informatics Institute faculty member Behçet Uğur Töreyin, Lütfiye Durak-Ata and Abdulkerim Çapar coauthored paper titled 'A whole-slide image grading benchmark and tissue classification for cervical cancer precursor lesions with inter-observer variability' has been published in 'Medical & Biological Engineering & Computing' in 2021. 

DOI: https://doi.org/10.1007/s11517-021-02388-w

Cite:
Albayrak, A., Akhan, A.U., Calik, N., Capar, A., Bilgin, G., Toreyin, B.U., Muezzinoglu, B., Turkmen, I. and Durak-Ata, L., 2021. A whole-slide image grading benchmark and tissue classification for cervical cancer precursor lesions with inter-observer variability. Medical & Biological Engineering & Computing, 59(7), pp.1545-1561.

Abstract: 
The cervical cancer developing from the precancerous lesions caused by the human papillomavirus (HPV) has been one of the preventable cancers with the help of periodic screening. Cervical intraepithelial neoplasia (CIN) and squamous intraepithelial lesion (SIL) are two types of grading conventions widely accepted by pathologists. On the other hand, inter-observer variability is an important issue for final diagnosis. In this paper, a whole-slide image grading benchmark for cervical cancer precursor lesions is created and the "Uterine Cervical Cancer Database" introduced in this article is the first publicly available cervical tissue microscopy image dataset. In addition, a morphological feature representing the angle between the basal membrane (BM) and the major axis of each nucleus in the tissue is proposed. The presence of papillae of the cervical epithelium and overlapping cell problems are also discussed. Besides that, the inter-observer variability is also evaluated by thorough comparisons among decisions of pathologists, as well as the final diagnosis

A whole-slide image grading benchmark-1

Date 03 Jan 2022

İTÜ Informatics Institute

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ITU Informatics Institute provides graduate-level education and research in applied informatics, computer sciences, computational science and engineering, communication systems under the following programs.

Faculty members and students conduct research supported by national and international organızatıons in the fields of electromagnetic fields, communication systems/regulations, computational materials design, computational chemistry/biology, cryptography, signal/data processing/visualization, big data management, climate and ocean sciences, 

  • The paper titled “Non-Invasive Complete Hemodynamic Model to Investigate the Effect of Multi-Stenosis in Patient-Specific Coronary Arteries”, jointly prepared by research assistants Hacer Duzman and E. Cenk Ersan, andProf. Dr. M. Serdar Çelebi from the Computational Science and Engineering Program, has been awarded the Best Paper Award at the ESM’25. (22-24 Oct. 2025 Belgium)
  • Hacer Duzman and Muhammed Enis Şen, PhD students of Computational Science and Engineering Program, received awards in the "5 Minute Thesis Competition" organized at the "Başarım 2024 8th National High Performance Computing Conference".

There is also a High Performance Computing Laboratory established with the support of the State Planning Organization within the Institute.

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