Enstitümüz Öğretim Üyelerinden Fethiye Aylin Sungur'un yazarları arasında olduğu 'Mechanistic insights into the challenges of organocatalytic Beckmann rearrangement reactions' başlıklı makale 'Organic & Biomolecular Chemistry' dergisinde 29 Aralık 2022 tarihinde yayınlanmıştır.

DOI: https://doi.org/10.1039/D2OB01641A

Organocatalytic Beckmann rearrangement (BKR) reactions are of great interest for synthetic chemists interested in “green chemistry”. There are different proposals for the reaction mechanism depending on the experimental conditions. Clarifying the details of the BKR reaction mechanism is important for the selectivity of amides and lactams yet to be synthesized. In this study, the DFT computational method at the M06-2X/6-31+G(d,p) level of theory in conjunction with the implicit PCM solvation method has been used to elucidate alternative pathways for the Beckmann rearrangement reaction at elevated temperatures. The results enabled us to explain details of the Beckmann rearrangement reaction via a Meisenheimer complex where the process was thermodynamically driven. Meisenheimer complexes are found to be highly stable species due to the presence of aromatic ring systems allowing electron delocalization.